The ODX ranges apply to adults, but are not designed to evaluate pregnancy at any stage.
The ODX optimal ranges apply to non-pregnant, non-lactating adults. They should not be used to clinically evaluate biomarkers during childhood, pregnancy, or lactation or for fertility evaluation purposes.
Several physiological changes occur during pregnancy, including hormonal, metabolic, coagulation, renal, and plasma volume changes. Notable changes occur with hormone production, including hCG, estrogen, progesterone, prolactin, lactogen, thyroid hormones, and fibrinogen. Pregnancy is also associated with Insulin resistance, plasma volume expansion, increased cardiac output, glomerular filtration rate, and renal plasma flow. Biomarker changes include decreased hemoglobin, red blood cells, creatinine, urea, and uric acid, as well as increased fibrinogen. Nutrient requirements also change, with a characteristic increased need for iron, folate, vitamin B12, and vitamin D increase. Several screening tests should also be carried out during pregnancy, including those for gestational diabetes, proteinuria, preeclampsia, and infections (Alkhatib 2018).
References
Abbassi-Ghanavati, Mina et al. “Pregnancy and laboratory studies: a reference table for clinicians.” Obstetrics and gynecology vol. 114,6 (2009): 1326-1331. doi:10.1097/AOG.0b013e3181c2bde8
Alkhatib, Adnan. “The Role of Laboratory Medicine for Health During Pregnancy.” EJIFCC vol. 29,4 280-284. 5 Dec. 2018
James, David et al. “Pregnancy and laboratory studies: a reference table for clinicians.” Obstetrics and gynecology vol. 115,4 (2010): 868. doi:10.1097/AOG.0b013e3181d7131e