MID refers to a group of WBCs that is determined by a particular size and includes monocytes, eosinophils, basophils, and blasts, but not neutrophils or lymphocytes. GRAN refers to granulocytes, a type of white blood cell with similar characteristics
A CBC with differential provides the total white blood cell (WBC) count as well as a breakdown of the different types of WBCs (Pagana 2021):
- WBCs can be either granulocytes or nongranulocytes
- Granulocytes include neutrophils, basophil/mast cells, and eosinophils
- Neutrophils are the most common granulocytes.
- Immature neutrophils are called bands or stab cells.
- Nongranulocytes include lymphocytes, monocytes, and histiocytes (macrophages that reside within tissues)
The mid-range (MID) value on a CBC with diff refers to “monocytes, eosinophils, basophils, blasts and other precursor white cells that fall in a particular size range.”
Increased levels of MID counts, neutrophils, and lymphocytes may reflect systemic inflammation, including inflammation caused by cigarette smoking and occupational dust exposure (Kong 2021).
A designated value for MID or GRAN may not be included in all laboratory reports.
References
Kong, Nan et al. “Blood leukocyte count as a systemic inflammatory biomarker associated with a more rapid spirometric decline in a large cohort of iron and steel industry workers.” Respiratory research vol. 22,1 254. 26 Sep. 2021, doi:10.1186/s12931-021-01849-y https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/34565362/
Pagana, Kathleen Deska, et al. Mosby's Diagnostic and Laboratory Test Reference. 15th ed., Mosby, 2021.