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Why are the female hormone optimal ranges so variable and not related to the female menstrual cycle?

Female hormone ranges for estradiol and progesterone vary based on when in the cycle the blood draw was made. We have not yet built in the capacity to do a more nuanced blood analysis of female hormones based on the menstrual cycle and the software makes no assumptions where in the cycle the blood draw was made. That being said, here's what information we do have on the ranges used in the software:

For Serum Estradiol 

The optimal and "normal" reference ranges used in the ODX Application for serum estradiol are set for the middle of the menstrual cycle (Mid-Cycle) or around day 14 and are Quest reference ranges. 

Quest Standard Reference Ranges

  • Follicular Phase: 19 -144 pg/ml
  • Mid-Cycle: 64 - 357 pg/ml
  • Luteal Phase: 56 - 214 pg/ml
  • Post-Menopausal: < or = to 30 pg/ml

For Serum Progesterone

The optimal and "normal" reference ranges used in the Optimal DX Application are specific for a menstruating female in the luteal phase of her cycle (day 21).

Quest Standard Reference Ranges

  • Follicular Phase  <1.0    ng/mL or <3.18 nmol/L
  • Luteal Phase 2.6 - 21.5    ng/mL or 8.27 - 68.37 nmol/L
  • Postmenopausal    <0.5    ng/mL or <1.59 nmol/L

We look at female hormone testing of estradiol and progesterone in blood as a gateway test to doing salivary hormone or DUTCH testing. We feel that these "advanced" tests are perhaps the best way to analyze estradiol and progesterone to give an analysis based on the phase of the cycle. 


Question: My 55-yo female is being flagged for a high probability of dysfunction for Sex Hormones because of low estradiol and progesterone but she's postmenopausal. How can I use the report in the most effective way?

Unfortunately, at present, we do not yet have the ability to vary the reporting based on variabilities in female hormones, such as postmenopausal estrogen and progesterone testing.